Cipemastat, marimastat, periostat, ilomastat and batimastat are all hydroxamate-based inhibitors of matrix metalloproteinase and are by so used in management of cardiovascular diseases. Hydroxamates such as fosmidomycin and desferrioxamine B are potent antimalarial agent. Hydroxyurea are also used for treatment of chronic myelogenal leukemia, myeloproliferative syndromes and sickle cell anemia. There are hydroxamates with reported anti-HIV activity such as the hydroxyurea which acts as inhibitors of cellular enzyme ribonucleoside diphosphate reductase. They have found applications as histone deacetylase inhibitors widely applied in cancer treatment such as vorinostat, belinostat, panobinostat and trichostatin A. Hydroxamates are physiologically active compounds. Ugwu, Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria.Email:Ĭopyright 2014 Scientific Academic Publishing. Ugwuja3ġDepartment of Pure and Industrial Chemistry, University of Nigeria, Nsukka, NigeriaĢNational Centre for Energy Research and Development, University of Nigeria, Nsukka, NigeriaģDepartment of Chemical Sciences, Federal University, Wukari, NigeriaĬorrespondence to: David I. The C-N C N-C core of carbodiimides N C N is linear, being related to the negatively charged oxygen must first be activated into a better leaving group.ĭavid I. From the perspective of small molecule activation, carbodiimides are. Carbodiimides hydrolyze to form ureas, which makes them uncommon in.Ĭarbodiimides hydrolyze to form ureas, which makes them uncommon in nature. A carbodiimide or a methanediimine is a functional group consisting of the formula RN C NR. They have found applications as histone deacetylase inhibitors widely applied in cancer treatment such as.

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